Recombinant fragment with tag: MEERMEMISE RPKESMYSWN KTAEKSDFEA VEALMSMSCS WKSDFKKYVE NRPVTPVSDL SEEENLLPGT PDFHTIPAFC LTPPYSPSDF EPSQVSNLMA PAPSTVHFKS , corresponding to amino acids 1-110 of Human KLF10
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent dilution. Detects a band of approximately 45 kDa (predicted molecular weight: 53 kDa).
Use at an assay dependent dilution.
RelevanceKLF10 (Krueppel-like factor 10), also known as TIEG1, is a transcription factor that plays a role in the regulation of cell growth. It binds to the consensus sequence 5'-GGTGTG-3'. KLF10 plays a role in the response to TGFbeta (through the TGFbeta/Smad signalling pathway) and estrogen. In both cases, KLF10 induces or repressed gene transcription to enhance the TGFbeta/Smad signalling pathway, as well as other pathways, to regulate cell proliferation, differentiation and apoptosis. KLF10 has been shown to have a role in skeletal disease (osteopenia/osteoporosis), hypertrophic cardiomyopathy, and breast and prostate cancer.