Overview

  • Product name
  • Description
    Rabbit polyclonal to KLF10
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: IP
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Horse, Cow, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Other
  • Immunogen

    Synthetic peptide, corresponding to a region between residues 430 and 480 of human KLF10 (NP_005646.1)

  • Positive control
    • HeLa and 293T whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab85970 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000. Predicted molecular weight: 53 kDa.
  • Application notes
    Is unsuitable for IP.
  • Target

    • Function
      Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.
    • Sequence similarities
      Belongs to the Sp1 C2H2-type zinc-finger protein family.
      Contains 3 C2H2-type zinc fingers.
    • Post-translational
      modifications
      Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Early growth response, alpha antibody
      • Early growth response, alpha like antibody
      • EGR A antibody
      • EGR alpha antibody
      • EGR(A) antibody
      • EGR-alpha antibody
      • EGRA antibody
      • Egral antibody
      • EGRalpha antibody
      • Gdnfif antibody
      • KLF 10 antibody
      • KLF10 antibody
      • KLF10_HUMAN antibody
      • Krueppel like factor 10 antibody
      • Krueppel like factor10 antibody
      • Krueppel-like factor 10 antibody
      • Kruppel like factor 10 antibody
      • mGIF antibody
      • TGF-beta- inducible early gene antibody
      • TGFB inducible early growth response 1 antibody
      • TGFB inducible early growth response antibody
      • TGFB inducible early growth response protein 1 antibody
      • TGFB-inducible early growth response protein 1 antibody
      • TIEG 1 antibody
      • TIEG antibody
      • TIEG-1 antibody
      • TIEG1 antibody
      • Transforming growth factor beta inducible early growth response antibody
      • Transforming growth factor beta inducible early growth response protein 1 antibody
      • Transforming growth factor-beta-inducible early growth response protein 1 antibody
      • Zinc finger transcription factor TIEG antibody
      see all

    Images

    • All lanes : Anti-KLF10 antibody (ab85970) at 0.04 µg/ml

      Lane 1 : HeLa whole cell lysate at 50 µg
      Lane 2 : HeLa whole cell lysate at 15 µg
      Lane 3 : HeLa whole cell lysate at 5 µg
      Lane 4 : 293T whole cell lysate at 50 µg


      Predicted band size : 53 kDa


      Exposure time : 30 seconds

    References

    This product has been referenced in:
    • Parakati R & DiMario JX Repression of myoblast proliferation and fibroblast growth factor receptor 1 promoter activity by KLF10 protein. J Biol Chem 288:13876-84 (2013). WB . Read more (PubMed: 23569208) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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