Anti-KLF10/11 antibody (ab111080)

Overview

  • Product nameAnti-KLF10/11 antibody
  • Description
    Rabbit polyclonal to KLF10/11
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthesized peptide derived from an internal region of Human KLF10/11.

  • Positive control
    • Human brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab111080 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionTranscription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.
  • Tissue specificityUbiquitous. Higher expression in erythroid cells.
  • Involvement in diseaseDefects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7) [MIM:610508]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • Sequence similaritiesBelongs to the Sp1 C2H2-type zinc-finger protein family.
    Contains 3 C2H2-type zinc fingers.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • AI115143 antibody
    • EGR[a] antibody
    • EGRA antibody
    • Egral antibody
    • Gdnfif antibody
    • KLF10 antibody
    • Klf11 antibody
    • KLF11_HUMAN antibody
    • Krueppel-like factor 11 antibody
    • Kruppel like factor 10 antibody
    • TGFB inducible early growth response antibody
    • TGFB-inducible early growth response protein 2 antibody
    • TIEG antibody
    • TIEG-2 antibody
    • TIEG1 antibody
    • Transforming growth factor-beta-inducible early growth response protein 2 antibody
    see all

Anti-KLF10/11 antibody images

  • ab111080 at 1/50 dilution staining KLF10/11 in paraffin-embedded Human Brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

References for Anti-KLF10/11 antibody (ab111080)

ab111080 has not yet been referenced specifically in any publications.

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