General notesPrincipal Names – KLF8; Kruppel-like factor 8; BKLF3; DXS741; ZNF741; zinc finger protein 741.
Official Gene Symbol - KLF8.
GenBank Accession Number – NP_009181.
LocusLink ID - 11279 (human)
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesWestern Blot: Approx 50kDa band seen in Human Kidney lysate.
Predicted molecular weight: 40 kDa.
Recommended for use at 1.0-3.0µg/ml.
FunctionTranscriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).
Sequence similaritiesBelongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.
Post-translational modificationsSumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no effect on subcellular location.