Overview

  • Product name
  • Description
    Goat polyclonal to KLF8
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity

    Predicted to work with: Human
  • Immunogen

    Synthetic peptide:

    VDMDKLINNLEVQ

    , corresponding to N terminal amino acids 2-14 of Human KLF8.

  • Positive control
    • Human Kidney lysate.
  • General notes
    Principal Names – KLF8; Kruppel-like factor 8; BKLF3; DXS741; ZNF741; zinc finger protein 741. Official Gene Symbol - KLF8. GenBank Accession Number – NP_009181. LocusLink ID - 11279 (human)

Properties

Applications

Our Abpromise guarantee covers the use of ab2747 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    Western Blot: Approx 50kDa band seen in Human Kidney lysate.
    Predicted molecular weight: 40 kDa.
    Recommended for use at 1.0-3.0µg/ml.
  • Target

    • Function
      Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).
    • Tissue specificity
      Ubiquitous.
    • Sequence similarities
      Belongs to the Sp1 C2H2-type zinc-finger protein family.
      Contains 3 C2H2-type zinc fingers.
    • Post-translational
      modifications
      Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no effect on subcellular location.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Basic krueppel-like factor 3 antibody
      • BKLF3 antibody
      • DXS741 antibody
      • KLF8 antibody
      • KLF8_HUMAN antibody
      • Krueppel-like factor 8 antibody
      • Kruppel like factor 8 antibody
      • MGC138314 antibody
      • Zinc finger protein 741 antibody
      • ZNF741 antibody
      see all

    Images

    References

    ab2747 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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