Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/MLL3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.
Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver.
This antibody gave a positive result in ELISA against the immunizing peptide (ab41903, blue). It gave a negative result in ELISA against the non-modified equivalent peptide (ab41904, yellow). This indicates that it is specific for the modified peptide.
References for Anti-KMT2C / MLL3 (acetyl K2809) antibody (ab40973)
has not yet been referenced specifically in any publications.
Publishing research using ab40973? Please let us know so that we can cite the reference in this datasheet.
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