This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

Anti-KMT2C / MLL3 (acetyl K2809) antibody (ab40973)

Overview

  • Product nameAnti-KMT2C / MLL3 (acetyl K2809) antibody
  • Description
    Rabbit polyclonal to KMT2C / MLL3 (acetyl K2809)

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • Species reactivity

    Predicted to work with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 2800 - 2850 of Human KMT2C/ MLL3.

    (Peptide available as ab41903.)

Properties

Associated products

Applications

  • Application notes
    This antibody gave a positive result in ELISA against the immunizing peptide (ab41903). It gave a negative result in ELISA against the non-modified equivalent peptide (ab41904). This indicates that it is specific for the modified peptide.
    See figure below.
    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionHistone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/MLL3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.
    • Tissue specificityHighly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver.
    • Sequence similaritiesBelongs to the histone-lysine methyltransferase family. TRX/MLL subfamily.
      Contains 1 A.T hook DNA-binding domain.
      Contains 1 DHHC-type zinc finger.
      Contains 6 PHD-type zinc fingers.
      Contains 1 post-SET domain.
      Contains 1 RING-type zinc finger.
      Contains 1 SET domain.
    • DomainThe SET domain interacts with histone H3 but not H2A, H2B and H4, and may have a H3 lysine specific methylation activity.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Histone-lysine N-methyltransferase MLL3 antibody
      • Homologous to ALR protein antibody
      • KMT2C antibody
      • Lysine N-methyltransferase 2C antibody
      • MLL3 antibody
      • MLL3_HUMAN antibody
      • Myeloid/lymphoid or mixed-lineage leukemia protein 3 antibody
      • Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog antibody
      see all

    Anti-KMT2C / MLL3 (acetyl K2809) antibody images

    This Fast-Track antibody is not yet fully characterised. These images represent inconclusive preliminary data.

    • This antibody gave a positive result in ELISA against the immunizing peptide (ab41903, blue). It gave a negative result in ELISA against the non-modified equivalent peptide (ab41904, yellow). This indicates that it is specific for the modified peptide.  

    References for Anti-KMT2C / MLL3 (acetyl K2809) antibody (ab40973)

    ab40973 has not yet been referenced specifically in any publications.

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