• Product nameAnti-KMT3B / NSD1 antibody [2658C1a]
    See all KMT3B / NSD1 primary antibodies
  • Description
    Mouse monoclonal [2658C1a] to KMT3B / NSD1
  • Tested applicationsSuitable for: WB, Dot Blotmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment derived from internal sequence of human KMT3B/ NSD1.

  • Positive control
    • Recombinant human KMT3B / NSD1.



Our Abpromise guarantee covers the use of ab70732 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 297 kDa.
Dot Blot Use at an assay dependent dilution.


  • FunctionHistone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context.
  • Tissue specificityExpressed in the fetal/adult brain, kidney, skeletal muscle, spleen, and the thymus, and faintly in the lung.
  • Involvement in diseaseDefects in NSD1 are the cause of Sotos syndrome (SOTOSS) [MIM:117550]; also known as cerebral gigantism. It is a disorder characterized by excessively rapid growth, acromegalic features, and a nonprogressive cerebral disorder with mental retardation. High-arched palate and prominent jaw are noted in several patients. Most cases of Sotos syndrome are sporadic and may represent new dominant mutation.
    Defects in NSD1 are the cause of Weaver syndrome (WES) [MIM:277590]. WES is a syndrome of accelerated growth and osseous maturation, unusual craniofacial appearance, hoarse and low-pitched cry, and hypertonia with camptodactyly.
    Defects in NSD1 are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
    Note=A chromosomal aberration involving NSD1 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NUP98.
    Note=A chromosomal aberration involving NSD1 is found in an adult form of myelodysplastic syndrome (MDS). Insertion of NUP98 into NSD1 generates a NUP98-NSD1 fusion product.
  • Sequence similaritiesBelongs to the histone-lysine methyltransferase family.
    Contains 1 AWS domain.
    Contains 4 PHD-type zinc fingers.
    Contains 1 post-SET domain.
    Contains 2 PWWP domains.
    Contains 1 SET domain.
  • Cellular localizationNucleus. Chromosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Androgen receptor coactivator 267 kDa protein antibody
    • Androgen receptor-associated protein of 267 kDa antibody
    • ARA267 antibody
    • H3 K36 HMTase antibody
    • H3-K36-HMTase antibody
    • H4 K20 HMTase antibody
    • H4-K20-HMTase antibody
    • Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific antibody
    • KMT3B antibody
    • Lysine N-methyltransferase 3B antibody
    • NR binding SET domain containing protein antibody
    • NR-binding SET domain-containing protein antibody
    • Nsd1 antibody
    • NSD1_HUMAN antibody
    • Nuclear receptor binding SET domain containing protein 1 antibody
    • Nuclear receptor-binding SET domain-containing protein 1 antibody
    see all

Anti-KMT3B / NSD1 antibody [2658C1a] images

References for Anti-KMT3B / NSD1 antibody [2658C1a] (ab70732)

This product has been referenced in:
  • Benedikt A  et al. The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures. Leukemia 25:135-44 (2011). WB ; Human . Read more (PubMed: 21030982) »

See 1 Publication for this product

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Thank you for your reply which has been forwarded to me as my colleague Anja is currently away from the office.

I can confirm we can offer you a discount for a future purchase if you would like to buy ab70732 now at full price and test it in...

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Thank you very much for your interest our AbTrial program.

To our knowledge, ab70732 has not been tested in CHIP. I have to confirm that we also do not offer any anti KMT3B / NSD1 antibodies that are tested and guaranteed for CHIP.
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