• Product nameAnti-KMT8/Riz1/Riz2 antibody
  • Description
    Rabbit polyclonal to KMT8/Riz1/Riz2
  • SpecificityThis antibody recognizes the beta isoform (Riz 2) of PRDM 2 (185 kDa) as well as RIZ 1. It will not detect isoform 4.
  • Tested applicationsSuitable for: IP, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Fusion protein (GST-tag) corresponding to Rat KMT8/Riz1/Riz2 aa 245-573.

  • Positive control
    • IP: Rat B50 brain tumour cell lysate.



Our Abpromise guarantee covers the use of ab3790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 189 kDa. PubMed: 24423864
IHC-P 1/100 - 1/500.


  • FunctionS-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
  • Tissue specificityHighly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3.
  • Sequence similaritiesContains 8 C2H2-type zinc fingers.
    Contains 1 SET domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • GATA 3 binding protein G3B antibody
    • GATA-3-binding protein G3B antibody
    • HUMHOXY1 antibody
    • Lysine N methyltransferase 8 antibody
    • Lysine N-methyltransferase 8 antibody
    • MTB ZF antibody
    • MTB-ZF antibody
    • MTE binding protein antibody
    • MTE-binding protein antibody
    • PR domain containing 2 with ZNF domain antibody
    • PR domain containing protein 2 antibody
    • PR domain zinc finger protein 2 antibody
    • PR domain-containing protein 2 antibody
    • PRDM2 antibody
    • PRDM2_HUMAN antibody
    • Retinoblastoma protein binding zinc finger protein antibody
    • Retinoblastoma protein interacting zinc- inger protein antibody
    • Retinoblastoma protein-interacting zinc finger protein antibody
    • RIZ antibody
    • RIZ-LSB antibody
    • RIZ1 antibody
    • RIZ2 antibody
    • Zinc finger DNA binding protein antibody
    • Zinc finger protein RIZ antibody
    see all

Anti-KMT8/Riz1/Riz2 antibody images

  • Rat B50 brain tumor cell extracts were immunoprecipitated with RIZ antibody or preimmune (Liu L. et al. J. Biol. Chem. 1997. 272: 2984.).

  • Immunohistochemical analysis of RIZ1 in adenovirus-transduced tumor cells. Established HCT116 xenograft tumors at day 2 after infection of AdRIZ1, Adnull, or buffer alone were processed for RIZ1 in situ detection (TUNEL) analysis (Jiang G-L. and Huang S. Cancer Res. 2001. 61: 1796.)

References for Anti-KMT8/Riz1/Riz2 antibody (ab3790)

This product has been referenced in:
  • Congdon LM  et al. The PR-Set7 binding domain of Riz1 is required for the H4K20me1-H3K9me1 trans-tail 'histone code' and Riz1 tumor suppressor function. Nucleic Acids Res 42:3580-9 (2014). WB ; Human . Read more (PubMed: 24423864) »
  • Zhou W  et al. Requirement of RIZ1 for cancer prevention by methyl-balanced diet. PLoS ONE 3:e3390 (2008). WB ; Mouse . Read more (PubMed: 18852888) »

See all 2 Publications for this product

Product Wall

Thank you for contacting Abcam.

We recently spoke on the phone regarding a Histone H3 methylation study. Below I have summarized our conversation and answers to your questions.

For detecting nuclear proteins via western blot we recomm...

Read More

This antibody has been cited in multiple publications (see list below) as KG7.1S serum by the leader in PRDM2 research. The discrepancies between theorical MWs and observed MWs are due to the experimental procedure (IP and WB) that will detect post-tra...

Read More