KRIBB3 (5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole) (ab146011)

Overview

  • Product name
    KRIBB3 (5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole)
  • Description
    Selective Hsp27 inhibitor. Microtubule inhibitor.
  • Biological description
    Selective Hsp27 inhibitor. Microtubule inhibitor. Inhibits PKC-dependent Hsp27-phosphorylation. Induces mitotic arrest and apoptosis in cancer cells. Shows antitumor effects in vivo.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Ryazantseva NV  et al. Role of heat shock protein 27 in regulation of glutathione system and apoptosis of jurkat tumor cells and blood lymphocytes. Bull Exp Biol Med 158:377-9 (2015). Read more (PubMed: 25573372) »
  • Shin KD  et al. KRIBB3, a novel microtubule inhibitor, induces mitotic arrest and apoptosis in human cancer cells. Biochem Pharmacol 75:383-94 (2008). Read more (PubMed: 17915194) »
  • Shin KD  et al. Blocking tumor cell migration and invasion with biphenyl isoxazole derivative KRIBB3, a synthetic molecule that inhibits Hsp27 phosphorylation. J Biol Chem 280:41439-48 (2005). Read more (PubMed: 16234246) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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