Overview

  • Product nameAnti-KRT75 antibody
  • Description
    Rabbit polyclonal to KRT75
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cat, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 1-50 (MSRQSSITFQ SGSRRGFSTT SAITPAAGRS RFSSVSVARS AAGSGGLGRI) of Human KRT75 (NP_004684).

  • Positive control
    • HT1080 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab94853 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 60 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionPlays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.
  • Tissue specificityHighly expressed in hair follicles from scalp. Specifically expressed in the of the hair companion layer follicle, a single layered band of flat and vertically oriented cells between the cuboidal outer root sheath (ORS) cells and the inner root sheath (IRS) that stretches from the lowermost bulb region to the isthmus of the follicle. Also expressed in medullated hairs. In nails, it is almost exclusively present in the nail bed (at protein level).
  • Involvement in diseaseDefects in KRT75 may be a cause of loose anagen hair syndrome (LAHS) [MIM:600628]. In LAHS, anagen hairs are easily pulled from the scalp. The hair is relatively sparse and does not grow long. Hair of fair color and hair shafts of reduced caliber, and an early age of onset are features. Usually the hairs are not fragile and there are no areas of breakage.
  • Sequence similaritiesBelongs to the intermediate filament family.
  • Information by UniProt
  • Database links
  • Alternative names
    • CK-75 antibody
    • CK75 antibody
    • Cytokeratin 75 antibody
    • Cytokeratin-75 antibody
    • hK6hf antibody
    • K2C75_HUMAN antibody
    • K6HF antibody
    • K75 antibody
    • KB18 antibody
    • Keratin 6 hair follicle antibody
    • Keratin 75 antibody
    • Keratin antibody
    • Keratin type II cytoskeletal 75 antibody
    • Keratin-6 hair follicle antibody
    • Keratin-75 antibody
    • Krt75 antibody
    • PFB antibody
    • type II cytoskeletal 75 antibody
    • Type II keratin 18 antibody
    • Type II keratin-K6hf antibody
    • Type-II keratin Kb18 antibody
    see all

Anti-KRT75 antibody images

  • Anti-KRT75 antibody (ab94853) at 1 µg/ml (in 5% skim milk / PBS buffer ) + HT1080 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 60 kDa

References for Anti-KRT75 antibody (ab94853)

ab94853 has not yet been referenced specifically in any publications.

Product Wall

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Expiration date: 25th September 2012.

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