Overview

  • Product name
  • Description
    Rabbit polyclonal to KRT81
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rhesus monkey
  • Immunogen

    Full length protein, corresponding to amino acids 1-202 of Human KRT81 (AAH21241.1).

  • Positive control
    • KRT81-transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab169303 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 21 kDa.

Target

  • Tissue specificity
    Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Expressed in malignant lymph node tissue in breast carcinoma tissue.
  • Involvement in disease
    Defects in KRT81 are a cause of monilethrix (MLTRX) [MIM:158000]. Monilethrix is an autosomal dominant hair disorder characterized clinically by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected.
  • Sequence similarities
    Belongs to the intermediate filament family.
  • Information by UniProt
  • Database links
  • Alternative names
    • 1 antibody
    • basic antibody
    • ghHb 1 antibody
    • ghHb1 antibody
    • ghHkb 1 antibody
    • ghHKb1 antibody
    • hair antibody
    • Hair keratin K2.9 antibody
    • Hard keratin type II 1 antibody
    • HB 1 antibody
    • HB1 antibody
    • hHAKB2 1 antibody
    • K2.9 antibody
    • K81 antibody
    • Keratin 81 antibody
    • Keratin antibody
    • Keratin hair basic 1 antibody
    • Keratin type II cuticular Hb1 antibody
    • Keratin-81 antibody
    • Keratin81 antibody
    • KRT 81 antibody
    • KRT81 antibody
    • KRT81_HUMAN antibody
    • KRTHB 1 antibody
    • KRTHB1 antibody
    • Metastatic lymph node 137 gene protein antibody
    • MLN 137 antibody
    • MLN137 antibody
    • type II cuticular Hb1 antibody
    • Type II hair keratin Hb1 antibody
    • Type-II keratin Kb21 antibody
    see all

Images

  • All lanes : Anti-KRT81 antibody (ab169303) at 1 µg/ml

    Lane 1 : KRT81-transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat Anti-Rabbit IgG (H+L)-HRP at 1/7500 dilution

    Developed using the ECL technique.

    Predicted band size: 21 kDa

References

ab169303 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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