Overview

  • Product name
  • Description
    Mouse monoclonal to KRT81
  • Tested applications
    Suitable for: WB, ICC/IF, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 304-505 of Human KRT81.

  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

Properties

Applications

Our Abpromise guarantee covers the use of ab55407 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ICC/IF
IHC-P
  • Application notes
    WB: Use at a concentration of 1-5 µg/ml.
    IF/ICC: Use at a concentration of 10 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Tissue specificity
      Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Expressed in malignant lymph node tissue in breast carcinoma tissue.
    • Involvement in disease
      Defects in KRT81 are a cause of monilethrix (MLTRX) [MIM:158000]. Monilethrix is an autosomal dominant hair disorder characterized clinically by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected.
    • Sequence similarities
      Belongs to the intermediate filament family.
    • Information by UniProt
    • Database links
    • Alternative names
      • 1 antibody
      • basic antibody
      • ghHb 1 antibody
      • ghHb1 antibody
      • ghHkb 1 antibody
      • ghHKb1 antibody
      • hair antibody
      • Hair keratin K2.9 antibody
      • Hard keratin type II 1 antibody
      • HB 1 antibody
      • HB1 antibody
      • hHAKB2 1 antibody
      • K2.9 antibody
      • K81 antibody
      • Keratin 81 antibody
      • Keratin antibody
      • Keratin hair basic 1 antibody
      • Keratin type II cuticular Hb1 antibody
      • Keratin-81 antibody
      • Keratin81 antibody
      • KRT 81 antibody
      • KRT81 antibody
      • KRT81_HUMAN antibody
      • KRTHB 1 antibody
      • KRTHB1 antibody
      • Metastatic lymph node 137 gene protein antibody
      • MLN 137 antibody
      • MLN137 antibody
      • type II cuticular Hb1 antibody
      • Type II hair keratin Hb1 antibody
      • Type-II keratin Kb21 antibody
      see all

    Images

    • KRT81 antibody (ab55407) used in immunofluorescence at 10ug/ml on HeLa cells.
    • KRT81 antibody (ab55407) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human esophagus.


    • Predicted band size : 55 kDa
      KRT81 antibody (ab55407) at 1ug/lane + HepG2 cell lysate at 25ug/lane.

    References

    ab55407 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab55407.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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