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Product name
KT5823
Description
Potent, selective inhibitor of PKG
Biological description
Potent, selective, reversible inhibitor of Protein Kinase G (PKG) (Ki = 234 nM). Derivative of K252, selective over PKA and PKC (Ki values are >10 µM and 4 µM respectively). Prevents increased phosphorylation of regulators of G-protein-signalling in vivo.
Purity
> 95%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
Molecular Weight
495.53
Chemical structure
Molecular formula
C29H25N3O5
CAS Number
126643-37-6
Solubility
Soluble in DMSO to 50 mM and in ethanol to 2.5 mM
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> Protein Kinase G >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for KT5823 (ab120423)
This product has been referenced in:
- Chan SL & Fiscus RR Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. Mol Hum Reprod 9:775-83 (2003).Read more (PubMed: 14614039) »
- Burkhardt M et al. KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. J Biol Chem 275:33536-41 (2000).Read more (PubMed: 10922374) »
See all 3 publications for this product
Publishing research using ab120423? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"