Overview

  • Product name
    KT5823
  • Description
    Potent, selective inhibitor of PKG
  • Biological description
    Potent, selective, reversible inhibitor of Protein Kinase G (PKG) (Ki = 234 nM). Derivative of K252, selective over PKA and PKC (Ki values are >10 and 4 μM, respectively). Prevents increased phosphorylation of regulators of G-protein-signalling in vivo.
  • Purity
    > 95%

Properties

  • Chemical name
    (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
  • Molecular weight
    495.53
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C29H25N3O5
  • CAS Number
    126643-37-6
  • PubChem identifier
    108152
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 50 mM and in ethanol to 2.5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    O=C(OC)[C@]8(C[C@H]7O[C@]8(C)n4c3c1n7c6ccccc6c1c2c(CN(C)C2=O)c3c5ccccc45)OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Chan SL & Fiscus RR Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. Mol Hum Reprod 9:775-83 (2003). Read more (PubMed: 14614039) »
  • Burkhardt M  et al. KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. J Biol Chem 275:33536-41 (2000). Read more (PubMed: 10922374) »
  • Levander-Lindgren M ECG telemetry for pacemaker check-up. Acta Med Scand Suppl 596:72-6 (1976). Read more (PubMed: 1070230) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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