Overview

  • Product nameAnti-Kv1.1 potassium channel antibody
    See all Kv1.1 potassium channel primary antibodies
  • Description
    Rabbit polyclonal to Kv1.1 potassium channel
  • Tested applicationsSuitable for: IHC-P, IHC-Fr, WB, IHC-FoFr, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from the C terminal domain of human Kv1.1 potassium channel.

Properties

Applications

Our Abpromise guarantee covers the use of ab65790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
WB 1/1000 - 1/5000. Detects a band of approximately 57 kDa (predicted molecular weight: 57 kDa).
IHC-FoFr Use at an assay dependent concentration. PubMed: 21752989
ICC/IF Use at an assay dependent concentration. PubMed: 19779067

Target

  • FunctionMediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
  • Involvement in diseaseDefects in KCNA1 are the cause of episodic ataxia type 1 (EA1) [MIM:160120]; also known as paroxysmal or episodic ataxia with myokymia (EAM) or paroxysmal ataxia with neuromyotonia. EA1 is an autosomal dominant disorder characterized by brief episodes of ataxia and dysarthria. Neurological examination during and between the attacks demonstrates spontaneous, repetitive discharges in the distal musculature (myokymia) that arise from peripheral nerve. Nystagmus is absent.
    Defects in KCNA1 are the cause of myokymia isolated type 1 (MK1) [MIM:160120]. Myokymia is a condition characterized by spontaneous involuntary contraction of muscle fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Isolated spontaneous muscle twitches occur in many persons and have no grave significance.
  • Sequence similaritiesBelongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily.
  • DomainThe N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Post-translational
    modifications
    Palmitoylated on Cys-243; which may be required for membrane targeting.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AEMK antibody
    • EA1 antibody
    • Episodic ataxia with myokymia antibody
    • HBK1 antibody
    • HUK1 antibody
    • Kca1 1 antibody
    • Kcna1 antibody
    • KCNA1_HUMAN antibody
    • Kcpvd antibody
    • KV1.1 antibody
    • MBK1 antibody
    • mceph antibody
    • MGC124402 antibody
    • MGC126782 antibody
    • MGC138385 antibody
    • MK1 antibody
    • MK1, mouse, homolog of KV1.1 antibody
    • Potassium channel protein 1 antibody
    • Potassium voltage gated channel shaker related subfamily member 1 antibody
    • Potassium voltage gated channel subfamily A member 1 antibody
    • Potassium voltage gated channel, shaker related subfamily, member 1 (episodic ataxia with myokymia) antibody
    • Potassium voltage-gated channel subfamily A member 1 antibody
    • RBK1 antibody
    • RCK1 antibody
    • Shak antibody
    • Shaker related subfamily member 1 antibody
    • Voltage gated potassium channel subunit Kv1.1 antibody
    • Voltage-gated K(+) channel HuKI antibody
    • Voltage-gated potassium channel HBK1 antibody
    • Voltage-gated potassium channel subunit Kv1.1 antibody
    see all

Anti-Kv1.1 potassium channel antibody images

  • All lanes : Anti-Kv1.1 potassium channel antibody (ab65790) at 1/500 dilution

    Lane 1 : Human brain tissue lysate - total protein (ab29466)
    Lane 2 : Human testis tissue lysate - total protein (ab30257)

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 57 kDa
    Observed band size : 57 kDa
    Additional bands at : 73 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 3 minutes

References for Anti-Kv1.1 potassium channel antibody (ab65790)

This product has been referenced in:
  • Viader A  et al. Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function. J Neurosci 31:10128-40 (2011). IHC-FoFr ; Mouse . Read more (PubMed: 21752989) »
  • Heeroma JH  et al. Episodic ataxia type 1 mutations differentially affect neuronal excitability and transmitter release. Dis Model Mech 2:612-9 (2009). ICC/IF ; Rat . Read more (PubMed: 19779067) »

See all 2 Publications for this product

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