Overview

  • Product name
  • Description
    Rabbit polyclonal to Kv2.2
  • Tested applications
    Suitable for: WB, IHC-FoFr, IHC-Frmore details
  • Species reactivity
    Reacts with: Rat, Xenopus laevis
  • Immunogen

    Peptide from the Kv2.2 subunit region of Xenopus and rodent, conjugated to KLH.

  • Positive control
    • rat brain

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: 50% Glycerol, 0.1% BSA, 150mM Sodium chloride, 10mM HEPES. pH 7.5
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab37195 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 102 kDa.
IHC-FoFr 1/800.
IHC-Fr 1/1000.

Target

  • Function
    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.
  • Sequence similarities
    Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
  • Domain
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • Post-translational
    modifications
    Phosphorylated.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • delayed rectifier potassium channel protein antibody
    • KCNB2 antibody
    • KCNB2_HUMAN antibody
    • potassium channel Kv2.2 antibody
    • potassium voltage gated channel subfamily B member 2 antibody
    • Potassium voltage-gated channel subfamily B member 2 antibody
    • Voltage-gated potassium channel subunit Kv2.2 antibody
    see all

Images

  • Immunohistochemistical detection of Kv2.2 antibody (ab37195) in PFA perfusion-fixed rat cortex sections. ab37195 was used at a dilution of 1/800, incubated for 18 hours @ 20°C in PBS-T 0.3%. Secondary antibody: Alexa Fluor® 488 anti-IgG Rabbit (1/1000). The staining is located in the processes of some neurons as expected.

    See Abreview

References

ab37195 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Abcam guarantees this product to work in the species/application used in this Abreview.
Application
Immunohistochemistry (PFA perfusion fixed frozen sections)
Sample
Rat Tissue sections (cortex)
Specification
cortex
Fixative
Paraformaldehyde
Permeabilization
No
Username

Dr. Karine Thibault

Verified customer

Submitted Oct 13 2010

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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