Overview

  • Product nameAnti-Kv4.2 antibody [EP982Y]
    See all Kv4.2 primary antibodies
  • Description
    Rabbit monoclonal [EP982Y] to Kv4.2
  • Tested applicationsSuitable for: WB, IHC-P, Flow Cytmore details
    Unsuitable for: ICC or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to residues near the C-terminus of Kv4.2 (Human).

  • Positive control
    • Human brain lysate; Human brain tissue.
  • General notes

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab46797 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 80 kDa.
IHC-P Use at an assay dependent concentration.
Flow Cyt 1/30.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

  • Application notesIs unsuitable for ICC or IP.
  • Target

    • FunctionPore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
    • Tissue specificityHighly expressed throughout the brain. Expression is very low or absent in other tissues.
    • Sequence similaritiesBelongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
    • DomainThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    • Post-translational
      modifications
      Phosphorylated on serine and threonine residues.
    • Cellular localizationCell membrane. Cell projection > dendrite. Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression.
    • Information by UniProt
    • Database links
    • Alternative names
      • KCD2 antibody
      • KCND 2 antibody
      • KCND2 antibody
      • KCND2_HUMAN antibody
      • KIAA1044 antibody
      • MGC119702 antibody
      • MGC119703 antibody
      • Potassium voltage gated channel Shal related subfamily member 2 antibody
      • Potassium voltage-gated channel subfamily D member 2 antibody
      • RK 5 antibody
      • RK5 antibody
      • Voltage gated potassium channel Kv4.2 antibody
      • Voltage gated potassium channel subunit Kv4.2 antibody
      • Voltage sensitive potassium channel antibody
      • Voltage-gated potassium channel subunit Kv4.2 antibody
      see all

    Anti-Kv4.2 antibody [EP982Y] images

    • Anti-Kv4.2 antibody [EP982Y] (ab46797) at 1/1000 dilution + Human brain lysate at 10 µg

      Secondary
      Goat anti-rabbit HRP at 1/2000 dilution

      Observed band size : 80 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 25 kDa. We are unsure as to the identity of these extra bands.

    References for Anti-Kv4.2 antibody [EP982Y] (ab46797)

    This product has been referenced in:
    • Aronica E  et al. Expression and localization of voltage dependent potassium channel Kv4.2 in epilepsy associated focal lesions. Neurobiol Dis 36:81-95 (2009). Read more (PubMed: 19596445) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"