Overview

  • Product nameKynurenic acid
  • Description
    Endogenous ionotropic / nicotinic antagonist
  • Biological descriptionEndogenous antagonist at ionotropic, glycine β and α7 nicotinic receptors. Neuroprotective in vivo. Water-soluble form available - please see Kynurenic acid sodium salt (ab120256)
  • Purity> 99%

Properties

    Associated products

    Kynurenic acid images

    • C1 and C2 - Inhibition of climbing fiber to Purkinje cell EPSCs in (control; black) by 1 mM Kynurenic acid (red, ab120064) or 100 nM NBQX (green, ab120045) recorded in 2.5 mM external Ca2+ at 0.05 Hz (C1) and 2 Hz (C2) stimulation frequency. D - Summary of inhibition of EPSCs by 1 mM Kynurenic acid (red, ab120064) and 100 nM NBQX (green, ab120045) in 2.5 mM external Ca2+.

    References for Kynurenic acid (ab120064)

    This product has been referenced in:
    • Grilli M  et al. Modulation of the function of presynaptic alpha7 and non-alpha7 nicotinic receptors by the tryptophan metabolites, 5-hydroxyindole and kynurenate in mouse brain. Br J Pharmacol 149:724-32 (2006). Read more (PubMed: 17016503) »
    • Pittaluga A  et al. The "kynurenate test", a biochemical assay for putative cognition enhancers. J Pharmacol Exp Ther 283:82-90 (1997). Read more (PubMed: 9336311) »
    • Hicks RR  et al. Kynurenate is neuroprotective following experimental brain injury in the rat. Brain Res 655:91-6 (1994). Read more (PubMed: 7812795) »

    See all 23 Publications for this product

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