Anti-kynurenine 3-monooxygenase antibody (ab167274)

Overview

  • Product name
    Anti-kynurenine 3-monooxygenase antibody
    See all kynurenine 3-monooxygenase primary antibodies
  • Description
    Mouse polyclonal to kynurenine 3-monooxygenase
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein corresponding to amino acids 1-407 of Human kynurenine 3-monooxygenase (Accession number AAH05297.1).

  • Positive control
    • kynurenine 3-monooxygenase transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab167274 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 51-55 kDa.

Target

  • Function
    Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
  • Tissue specificity
    Highest levels in placenta and liver. Detectable in kidney.
  • Pathway
    Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
  • Sequence similarities
    Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
  • Cellular localization
    Mitochondrion outer membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • dJ317G22.1 antibody
    • kmo antibody
    • KMO_HUMAN antibody
    • Kynurenine 3 hydroxylase antibody
    • Kynurenine 3 monooxygenase (kynurenine 3 hydroxylase) antibody
    • Kynurenine 3 monooxygenase antibody
    • Kynurenine 3-hydroxylase antibody
    • Kynurenine 3-monooxygenase antibody
    • RP1-317G22.1 antibody
    see all

Images

  • All lanes : Anti-kynurenine 3-monooxygenase antibody (ab167274) at 1 µg/ml

    Lane 1 : Kynurenine 3-monooxygenase transfected 293T cell lysate

    Lane 2 : Non-transfected lysate

    Lysates/proteins at 15 µl per lane.

    Developed using the ECL technique.

    Predicted band size: 51-55 kDa

References

ab167274 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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