Overview

  • Product name
    L-655,240
  • Description
    Potent thromboxane A2 receptor antagonist
  • Biological description
    Potent thromboxane A2 receptor antagonist (IC50 = 7 nM). Blocks TP-mediated bronchoconstriction in vivo and platelet aggregation ex vivo. Orally active in vivo.
  • Purity
    > 98%

Properties

  • Chemical name
    1-[(4-Chlorophenyl)methyl]-5-fluoro-α,α,3-trimethyl-1H-indole-2-propanoic acid
  • Molecular weight
    373.85
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C21H21ClFNO2
  • CAS Number
    103253-15-2
  • Storage instructions
    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 50 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    ClC1=CC=C(CN2C(CC(C)(C)C(O)=O)=C(C)C3=CC(F)=CC=C32)C=C1
  • Source

    Synthetic

  • Research areas

    References for L-655,240 (ab120946)

    This product has been referenced in:
    • Ogletree ML & Allen GT Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J Pharmacol Exp Ther 260:789-94 (1992). Read more (PubMed: 1531361) »
    • Wainwright CL & Parratt JR The effects of L655,240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia- and reperfusion-induced cardiac arrhythmias. J Cardiovasc Pharmacol 12:264-71 (1988). Read more (PubMed: 2464097) »
    • Hall RA  et al. Pharmacology of L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpro pan oic acid); a potent, selective thromboxane/prostaglandin endoperoxide antagonist. Eur J Pharmacol 135:193-201 (1987). Read more (PubMed: 3582493) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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