Biological descriptionHighly potent, selective 5-HT1D/5-HT1B receptor agonist (pIC50 values are 10.03 and 9.08 at 5-HT1D and5-HT1B receptors, respectively). Induces partial blockade of water intake.
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Bhalla P et al. Molecular cloning, pharmacological properties and tissue distribution of the porcine 5-HT(1B) receptor. Br J Pharmacol133:891-901 (2001).
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De Castro-e-Silva E et al. Effect of third ventricle administration of L-694,247, a selective 5-HT1D receptor agonist, on water intake in rats. Pharmacol Biochem Behav57:749-54 (1997).
Read more (PubMed: 9259002) »