Biological descriptionHighly potent and selective D4 antagonist (Ki values are 0.43, 2300 and 960 nM at D4, D3 and D2, respectively). Brain permeable. Inhibits cell death and shows neuroprotective effects.
Chemical name3-[4-(4-Chlorophenyl)piperazin-1-yl]-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for L-745870 trihydrochloride (ab120598)
This product has been referenced in:
Tanaka K et al. A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice. Exp Neurol211:378-86 (2008).
Read more (PubMed: 18423451) »
Mamiya T et al. Effects of L-745,870, a dopamine D4 receptor antagonist, on naloxone-induced morphine dependence in mice. Ann N Y Acad Sci1025:424-9 (2004).
Read more (PubMed: 15542745) »
Patel S et al. Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor. J Pharmacol Exp Ther283:636-47 (1997).
Read more (PubMed: 9353380) »