Overview

  • Product nameL-cis-Diltiazem
  • Description
    Selective cyclic nucleotide-gated channel blocker
  • Biological descriptionSelective inhibitor of cyclic nucleotide-gated (CNG) channels. Blocks rod-type CNGA1, olfactory-type CNGA2 and cone-type CNGA3, at micromolar concentrations. Optical isomer of diltiazem (ab120260). Protects against myocardial dysfunction in vitro.
  • Purity> 98%

Properties

  • Chemical name(2R,3R)-(-)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride
  • Molecular weight450.98
  • Chemical structureChemical Structure
  • Molecular formulaC22H26N2O4S.HCl
  • CAS Number42399-54-2
  • Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

    Associated products

    References for L-cis-Diltiazem (ab120532)

    This product has been referenced in:
    • Shalom R  et al. Interaction between prostaglandin E2 and l-cis-diltiazem, a specific blocker of cyclic nucleotide gated channels in bovine aortic endothelial cells. Eur J Pharmacol 543:8-13 (2006). Read more (PubMed: 16842773) »
    • Gomora JC & Enyeart JJ Dual pharmacological properties of a cyclic AMP-sensitive potassium channel. J Pharmacol Exp Ther 290:266-75 (1999). Read more (PubMed: 10381786) »
    • Haynes LW Block of the cyclic GMP-gated channel of vertebrate rod and cone photoreceptors by l-cis-diltiazem. J Gen Physiol 100:783-801 (1992). Read more (PubMed: 1282145) »
    • Frings S  et al. Properties of cyclic nucleotide-gated channels mediating olfactory transduction. Activation, selectivity, and blockage. J Gen Physiol 100:45-67 (1992). Read more (PubMed: 1324972) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"