Overview

  • Product nameAnti-L-Kynurenine Hydrolase antibody
    See all L-Kynurenine Hydrolase primary antibodies
  • Description
    Mouse monoclonal to L-Kynurenine Hydrolase
  • Tested applicationsSuitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 2-109 of Human L-Kynurenine Hydrolase

Properties

Applications

Our Abpromise guarantee covers the use of ab56450 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ICC/IF
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCatalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
    • Tissue specificityExpressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions.
    • PathwayAmino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.
      Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.
    • Involvement in diseaseNote=Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively.
    • Sequence similaritiesBelongs to the kynureninase family.
    • Cellular localizationCytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • kynU antibody
      • KYNU_HUMAN antibody
      • kynureninase (L-kynurenine hydrolase) antibody
      • Kynureninase antibody
      • L-kynurenine hydrolase antibody
      see all

    Anti-L-Kynurenine Hydrolase antibody images

    • Western blot against tagged recombinant protein immunogen using ab56450 L-Kynurenine Hydrolase antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    References for Anti-L-Kynurenine Hydrolase antibody (ab56450)

    This product has been referenced in:
    • Yang G  et al. Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. J Exp Med 210:241-56 (2013). ICC/IF . Read more (PubMed: 23359068) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"