Overview

  • Product name
    Anti-L-Kynurenine Hydrolase antibody
    See all L-Kynurenine Hydrolase primary antibodies
  • Description
    Rabbit polyclonal to L-Kynurenine Hydrolase
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 114 and 299 of Human L-Kynurenine Hydrolase (AAH00879).

  • Positive control
    • A549 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab96365 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 35 kDa.

Target

  • Function
    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
  • Tissue specificity
    Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions.
  • Pathway
    Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.
    Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.
  • Involvement in disease
    Note=Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively.
  • Sequence similarities
    Belongs to the kynureninase family.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • kynU antibody
    • KYNU_HUMAN antibody
    • kynureninase (L-kynurenine hydrolase) antibody
    • Kynureninase antibody
    • L-kynurenine hydrolase antibody
    see all

Images

  • Anti-L-Kynurenine Hydrolase antibody (ab96365) at 1/1000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size : 35 kDa

References

This product has been referenced in:
  • Nagy-Grócz G  et al. The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat. Front Neurol 8:278 (2017). WB ; Rat . Read more (PubMed: 28659861) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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