Anti-L-Kynurenine Hydrolase antibody (ab96365)

Overview

  • Product nameAnti-L-Kynurenine Hydrolase antibody
    See all L-Kynurenine Hydrolase primary antibodies
  • Description
    Rabbit polyclonal to L-Kynurenine Hydrolase
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 114 and 299 of Human L-Kynurenine Hydrolase (AAH00879).

  • Positive control
    • A549 cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab96365 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 35 kDa.

Target

  • FunctionCatalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
  • Tissue specificityExpressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions.
  • PathwayAmino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.
    Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.
  • Involvement in diseaseNote=Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively.
  • Sequence similaritiesBelongs to the kynureninase family.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • kynU antibody
    • KYNU_HUMAN antibody
    • kynureninase (L-kynurenine hydrolase) antibody
    • Kynureninase antibody
    • L-kynurenine hydrolase antibody
    see all

Anti-L-Kynurenine Hydrolase antibody images

  • Anti-L-Kynurenine Hydrolase antibody (ab96365) at 1/1000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size : 35 kDa

References for Anti-L-Kynurenine Hydrolase antibody (ab96365)

ab96365 has not yet been referenced specifically in any publications.

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