Overview

  • Product name
    L-Pyroglutamic acid
  • Description
    Metabolite in the glutathione cycle.
  • Alternative names
    • (-)-2-Pyrrolidone-5-carboxylic Acid
    • (-)-2-Pyrrolidone-5-carboxylic Acid
    • (-)-Pyroglutamic Acid
    • (2S)-5-Oxopyrrolidine-2-carboxylic Acid
    • (5S)-2-Oxopyrrolidine-5-carboxylic Acid
    • (S)-(-)-2-Pyrrolidone-5-carboxylic Acid
    • 5-Oxo-L-proline
    • L-Glutimic Acid
    see all
  • Biological description

    Cyclized derivative of L-Glutamic acid. Metabolite in the glutathione cycle.

Properties

  • Chemical name
    L-Pyroglutamic acid
  • Molecular weight
    129.11
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C5H7NO3
  • CAS Number
    98-79-3
  • Storage instructions
    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Liu YD  et al. N-terminal glutamate to pyroglutamate conversion in vivo for human IgG2 antibodies. J Biol Chem 286:11211-7 (2011). Read more (PubMed: 21282104) »
  • Wirths O  et al. Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis. J Biol Chem 285:41517-24 (2010). Read more (PubMed: 20971852) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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