Overview

  • Product nameAnti-L2HGDH antibody
  • Description
    Rabbit polyclonal to L2HGDH
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 139-167 of Human L2HGDH (NP_079160.1).

  • Positive control
    • MDA-MB435 cell line and Mouse kidney tissue lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab108012 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.

Target

  • Tissue specificityWidely expressed. Highly expressed in brain, testis and muscle. Expressed to a lower extent in lymphocytes, fibroblasts, keratinocytes, placenta, bladder, small intestine, liver and bone marrow.
  • Involvement in diseaseDefects in L2HGDH are the cause of L-2-hydroxyglutaric aciduria (L2HGA) [MIM:236792]. L2HGA is a rare autosomal recessive disorder clinically characterized by mild psychomotor delay in the first years of life, followed by progressive cerebellar ataxia, dysarthria and moderate to severe mental retardation. Diagnosis is based on the presence of an excess of L-2-hydroxyglutaric acid in urine, blood and cerebrospinal fluid.
  • Sequence similaritiesBelongs to the L2HGDH family.
  • Cellular localizationMitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2 hydroxyglutarate dehydrogenase antibody
    • Alpha hydroxyglutarate oxidoreductase antibody
    • Alpha ketoglutarate reductase antibody
    • C14orf160 antibody
    • Duranin antibody
    • FLJ12618 antibody
    • L alpha hydroxyglutarate dehydrogenase antibody
    • L-2-hydroxyglutarate dehydrogenase antibody
    • L-2-hydroxyglutarate dehydrogenase, mitochondrial antibody
    • L2HDH_HUMAN antibody
    • l2hgdh antibody
    • mitochondrial antibody
    see all

Anti-L2HGDH antibody images

  • Anti-L2HGDH antibody (ab108012) at 1/100 dilution + MDA-MB435 cell line lysates at 35 µg/ml

    Predicted band size : 50 kDa
  • Anti-L2HGDH antibody (ab108012) at 1/100 dilution + Mouse kidney tissue lysates at 35 µg

    Predicted band size : 50 kDa

References for Anti-L2HGDH antibody (ab108012)

ab108012 has not yet been referenced specifically in any publications.

Product Wall

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