Overview

  • Product name
  • Description
    Rabbit polyclonal to L2HGDH
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to Human L2HGDH aa 132-159 conjugated to keyhole limpet haemocyanin.
    Database link: Q9H9P8

  • Positive control
    • MDA-MB435 cell line and Mouse kidney tissue lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab108012 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 50 kDa.

Target

  • Tissue specificity
    Widely expressed. Highly expressed in brain, testis and muscle. Expressed to a lower extent in lymphocytes, fibroblasts, keratinocytes, placenta, bladder, small intestine, liver and bone marrow.
  • Involvement in disease
    Defects in L2HGDH are the cause of L-2-hydroxyglutaric aciduria (L2HGA) [MIM:236792]. L2HGA is a rare autosomal recessive disorder clinically characterized by mild psychomotor delay in the first years of life, followed by progressive cerebellar ataxia, dysarthria and moderate to severe mental retardation. Diagnosis is based on the presence of an excess of L-2-hydroxyglutaric acid in urine, blood and cerebrospinal fluid.
  • Sequence similarities
    Belongs to the L2HGDH family.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2 hydroxyglutarate dehydrogenase antibody
    • Alpha hydroxyglutarate oxidoreductase antibody
    • Alpha ketoglutarate reductase antibody
    • C14orf160 antibody
    • Duranin antibody
    • FLJ12618 antibody
    • L alpha hydroxyglutarate dehydrogenase antibody
    • L-2-hydroxyglutarate dehydrogenase antibody
    • L-2-hydroxyglutarate dehydrogenase, mitochondrial antibody
    • L2HDH_HUMAN antibody
    • l2hgdh antibody
    • mitochondrial antibody
    see all

Anti-L2HGDH antibody images

  • All lanes : Anti-L2HGDH antibody (ab108012) at 1/1000 dilution

    Lane 1 : Mouse kidney tissue lysates
    Lane 2 : MDA-MB435 cell line

    Lysates/proteins at 35 µg per lane.


    Predicted band size : 50 kDa

References for Anti-L2HGDH antibody (ab108012)

ab108012 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab108012.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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