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Potent Raf kinase inhibitor
Potent Raf kinase inhibitor (IC
50 = 10 nM). Inhibits Raf-1 activation. Competes for ATP at the protein kinase catalytic site. Supresses DNA synthesis and induces apoptosis. Additionally inhibits p38.
20H 14ClN 3O
Store at +4°C. The product can be stored for up to 12 months.
Soluble in DMSO to 100 mM and in ethanol to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our
frequently asked questions (FAQ) page for more details.
References for L779450 (ab120837)
This product has been referenced in:
et al. Raf-1 kinase regulates smooth muscle contraction in the rat mesenteric arteries. J Vasc Res 47:384-98 (2010).
Read more (PubMed: 20110729) »
Small-molecule inhibitors of signal transduction pathways in leukemia therapeutics: how to assess selectivity for malignant signals. Leukemia 17:1759-61 (2003).
Read more (PubMed: 12970775) »
et al. Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia 17:1765-82 (2003).
Read more (PubMed: 12970777) »
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for this product
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"