Anti-Lactoferrin antibody (ab112968)
Key features and details
- Goat polyclonal to Lactoferrin
- Suitable for: ELISA
- Reacts with: Cow
- Isotype: IgG
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Overview
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Product name
Anti-Lactoferrin antibody
See all Lactoferrin primary antibodies -
Description
Goat polyclonal to Lactoferrin -
Host species
Goat -
Tested applications
Suitable for: ELISAmore details -
Species reactivity
Reacts with: Cow -
Immunogen
Full length native protein (purified) corresponding to Cow Lactoferrin. bovine milk origin
Database link: P24627 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 6.8
Preservative: 0.09% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
Antiserum was solid phase adsorbed to ensure specificity. ab112968 was isolated by affinity chromatography using antigen coupled to agarose beads. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab112968 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ELISA |
Use at an assay dependent concentration.
Coating: Use 1/100-1/500 dilution; Primary: Use 1/1000-1/30000 dilution. |
Notes |
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ELISA
Use at an assay dependent concentration. Coating: Use 1/100-1/500 dilution; Primary: Use 1/1000-1/30000 dilution. |
Target
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Function
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.
Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration.
Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.
The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. -
Sequence similarities
Belongs to the transferrin family.
Contains 2 transferrin-like domains. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 280846 Cow
- SwissProt: P24627 Cow
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Alternative names
- GIG12 antibody
- Growth inhibiting protein 12 antibody
- HLF2 antibody
see all
Protocols
Datasheets and documents
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Datasheet download
References (3)
ab112968 has been referenced in 3 publications.
- Santos-Pereira C et al. Lactoferrin perturbs lipid rafts and requires integrity of Pma1p-lipid rafts association to exert its antifungal activity against Saccharomyces cerevisiae. Int J Biol Macromol 171:343-357 (2021). PubMed: 33421469
- Peng Z et al. Autophagy Induced by Palmitic Acid Regulates Neutrophil Adhesion Through the Granule-Dependent Degradation of αMβ2 Integrin in Dairy Cows With Fatty Liver. Front Immunol 12:726829 (2021). PubMed: 34691032
- Zhang SD et al. Differential proteomic profiling of endometrium and plasma indicate the importance of hydrolysis in bovine endometritis. J Dairy Sci 100:9324-9337 (2017). PubMed: 28918157