Overview

  • Product name
  • Description
    Rabbit polyclonal to LAMC2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Dog
  • Immunogen

    Recombinant protein fragment contain a sequence corresponding to a region within amino acids 445 and 627 of Human LAMC2

  • Positive control
    • Raji whole cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab96327 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 131 kDa.

Target

  • Function
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.
  • Tissue specificity
    The large variant is expressed only in specific epithelial cells of embryonic and neonatal tissues. In 17-week old embryo the small variant is found in cerebral cortex, lung, and distal tubes of kidney, but not in epithelia except for distal tubuli.
  • Involvement in disease
    Defects in LAMC2 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB) [MIM:226700]; also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs usually within the first six months of life. Occasionally, children survive to teens. H-JEB is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic.
  • Sequence similarities
    Contains 8 laminin EGF-like domains.
    Contains 1 laminin IV type A domain.
  • Domain
    The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
    Domain IV is globular.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix > basement membrane. Major component.
  • Information by UniProt
  • Database links
  • Alternative names
    • 3918 antibody
    • B2T antibody
    • BM600 antibody
    • Cell-scattering factor 140 kDa subunit antibody
    • CSF 140 kDa subunit antibody
    • CSF antibody
    • EBR2 antibody
    • EBR2A antibody
    • Epiligrin subunit gamma antibody
    • Kalinin subunit gamma antibody
    • Kalinin/nicein/epiligrin 100 kDa subunit antibody
    • Ladsin 140 kDa subunit antibody
    • LAMB2T antibody
    • LAMC2 antibody
    • LAMC2_HUMAN antibody
    • Laminin 5 gamma 2 subunit antibody
    • Laminin B2t chain antibody
    • Laminin gamma 2 antibody
    • laminin gamma 2 chain antibody
    • Laminin subunit gamma-2 antibody
    • Laminin-5 subunit gamma antibody
    • LAMNB2 antibody
    • Large adhesive scatter factor 140 kDa subunit antibody
    • MGC138491 antibody
    • MGC141938 antibody
    • Nicein subunit gamma antibody
    • NICEIN-100KDA antibody
    see all

Images

  • Anti-LAMC2 antibody (ab96327) at 1/1000 dilution + Raji cell lysate at 30 µg

    Predicted band size : 131 kDa

References

This product has been referenced in:

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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