Anti-Laminin 2 alpha antibody [2D4] (ab117608)

Overview

  • Product nameAnti-Laminin 2 alpha antibody [2D4]
    See all Laminin 2 alpha primary antibodies
  • Description
    Mouse monoclonal [2D4] to Laminin 2 alpha
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant Human Laminin Alpha 2 (NP_000417.2).

  • Positive control
    • Human Placenta (Trophoblast) tissue.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab117608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 344 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.

Target

  • FunctionBinding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • Tissue specificityPlacenta, striated muscle, peripheral nerve, cardiac muscle, pancreas, lung, spleen, kidney, adrenal gland, skin, testis, meninges, choroid plexus, and some other regions of the brain; not in liver, thymus and bone.
  • Involvement in diseaseDefects in LAMA2 are the cause of merosin-deficient congenital muscular dystrophy type 1A (MDC1A) [MIM:607855]. MDC1A is characterized by difficulty walking, hypotonia, proximal weakness, hyporeflexia, and white matter hypodensity on MRI.
  • Sequence similaritiesContains 17 laminin EGF-like domains.
    Contains 5 laminin G-like domains.
    Contains 2 laminin IV type A domains.
    Contains 1 laminin N-terminal domain.
  • DomainThe alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
    Domains VI, IV and G are globular.
  • Cellular localizationSecreted > extracellular space > extracellular matrix > basement membrane. Major component.
  • Information by UniProt
  • Database links
  • Alternative names
    • LAMA 2 antibody
    • LAMA2 antibody
    • LAMA2_HUMAN antibody
    • Laminin alpha 2 (merosin congenital muscular dystrophy) antibody
    • Laminin alpha 2 antibody
    • Laminin alpha 2 chain antibody
    • Laminin alpha 2 subunit antibody
    • Laminin M antibody
    • Laminin M chain antibody
    • Laminin subunit alpha-2 antibody
    • Laminin-12 subunit alpha antibody
    • Laminin-2 subunit alpha antibody
    • Laminin-4 subunit alpha antibody
    • LAMM antibody
    • Merosin heavy chain antibody
    see all

Anti-Laminin 2 alpha antibody [2D4] images

  • ab117608, at 5 µg/ml, staining Laminin 2 alpha in Formalin-fixed, Paraffin-embedded Human Placenta (Trophoblast) tissue by Immunohistochemistry.

References for Anti-Laminin 2 alpha antibody [2D4] (ab117608)

ab117608 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab117608.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"