Anti-Laminin alpha 4 antibody - C-terminal (ab154314)

Overview

  • Product name
    Anti-Laminin alpha 4 antibody - C-terminal
    See all Laminin alpha 4 primary antibodies
  • Description
    Rabbit polyclonal to Laminin alpha 4 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to a region within C-terminal amino acids 1581-1809 of Human Laminin alpha 4 (Q16363).

  • Positive control
    • PC14 xenograft.
  • General notes
    Keep as concentrated solution.

Properties

Applications

Our Abpromise guarantee covers the use of ab154314 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • Tissue specificity
    In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn tissues is observed in certain mesenchymal cells in tissues such as smooth muscle and dermis.
  • Involvement in disease
    Cardiomyopathy, dilated 1JJ
  • Sequence similarities
    Contains 4 laminin EGF-like domains.
    Contains 5 laminin G-like domains.
  • Domain
    The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
    Domain G is globular.
  • Cellular localization
    Secreted, extracellular space, extracellular matrix, basement membrane. Major component.
  • Information by UniProt
  • Database links
  • Alternative names
    • CMD1JJ antibody
    • DKFZp686D23145 antibody
    • LAMA3 antibody
    • LAMA3, formerly antibody
    • LAMA4 1 antibody
    • LAMA4 antibody
    • LAMA4*-1 antibody
    • LAMA4_HUMAN antibody
    • Laminin alpha 4 antibody
    • Laminin alpha 4 chain antibody
    • Laminin subunit alpha 4 precursor antibody
    • Laminin subunit alpha-4 antibody
    • Laminin-14 subunit alpha antibody
    • Laminin-8 subunit alpha antibody
    • Laminin-9 subunit alpha antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded PC14 xenograft labeling Laminin alpha 4 using ab154314 at 1/100 dilution.

References

ab154314 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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