Overview

  • Product name
    Anti-Laminin antibody, prediluted
    See all Laminin primary antibodies
  • Description
    Rabbit polyclonal to Laminin, prediluted
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Full length Laminin isolated from a rat yolk sac tumor cell line.

  • Positive control
    • Skin, Lung, Kidney or Tonsil tissue.
  • General notes


    This antibody labels basement membrane surrounding normal vessels, glands, muscles, nerves, fat and deciduas cells separating these from abutting connective tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab74164 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/1. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.

Ready to use.

Target

  • Function
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • Tissue specificity
    Broadly expressed in: skin, heart, lung, and the reproductive tracts.
  • Sequence similarities
    Contains 11 laminin EGF-like domains.
    Contains 1 laminin IV type A domain.
    Contains 1 laminin N-terminal domain.
  • Domain
    The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
    Domain IV is globular.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix > basement membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • LAMA 1 antibody
    • LAMA antibody
    • LAMA1 antibody
    • LAMB1 antibody
    • Lamc3 antibody
    • LAMC3_HUMAN antibody
    • Laminin A chain antibody
    • Laminin alpha 1 antibody
    • Laminin alpha 1 chain antibody
    • Laminin B1 chain antibody
    • Laminin subunit beta 1 antibody
    • Laminin subunit gamma-3 antibody
    • Laminin-12 subunit gamma antibody
    • Laminin-14 subunit gamma antibody
    • Laminin-15 subunit gamma antibody
    see all

Images

  • ab74164 staining Laminin in human skin by Immunohistochemistry, Formalin-fixed, paraffin-embedded tissue using peroxidase-conjugate and AEC chromogen. Note staining of basement membranes of epidermis and surrounding blood vessels.

References

This product has been referenced in:
  • Baert Y  et al. Derivation and characterization of a cytocompatible scaffold from human testis. Hum Reprod 30:256-67 (2015). Read more (PubMed: 25505010) »
  • Balestrini JL  et al. Production of decellularized porcine lung scaffolds for use in tissue engineering. Integr Biol (Camb) 7:1598-610 (2015). Read more (PubMed: 26426090) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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