Overview

  • Product name
  • Description
    Mouse polyclonal to LANCL2
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human LANCL2 protein (NP_061167.1).

  • Positive control
    • WB: A431 cell lysate; LANCL2 transfected 293T cell lysate ICC/IF: HeLa cell

Properties

Applications

Our Abpromise guarantee covers the use of ab88860 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 51 kDa.
ICC/IF Use a concentration of 10 µg/ml.

Target

  • Function
    Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
  • Tissue specificity
    Expressed in brain and testis.
  • Sequence similarities
    Belongs to the LanC-like protein family.
  • Post-translational
    modifications
    Myristoylated. Essential for membrane association.
  • Cellular localization
    Nucleus. Cytoplasm. Cell membrane. Localizes to the juxta-nuclear vesicles. Associates with the cortical actin cytoskeleton. Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo. Membrane-association is important for the increased cellular sensitivity to an anticancer drug.
  • Information by UniProt
  • Database links
  • Alternative names
    • G protein coupled receptor 69B antibody
    • GPR69B antibody
    • LanC (bacterial lantibiotic synthetase component C) like 2 antibody
    • LanC-like protein 2 antibody
    • LANC2_HUMAN antibody
    • LANCL2 antibody
    • TASP antibody
    • Testis specific adriamycin sensitivity protein antibody
    • Testis-specific adriamycin sensitivity protein antibody
    see all

Images

  • Anti-LANCL2 antibody (ab88860) at 1 µg/ml + A431 cell lysate at 50 µg

    Predicted band size : 51 kDa
    Observed band size : ~48 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-LANCL2 antibody (ab88860) at 1 µg/ml

    Lane 1 : LANCL2 transfected 293T cell lysate
    Lane 2 : non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 51 kDa
    Observed band size : ~45 kDa (why is the actual band size different from the predicted?)
  • ab88860, at 10 µg/ml, staining LANCL2 in paraformaldehyde fixed, permeabilized HeLa cell by Immunofluorescence.

References

ab88860 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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