Anti-Langerin antibody (ab125476)


  • Product nameAnti-Langerin antibody
    See all Langerin primary antibodies
  • Description
    Rabbit polyclonal to Langerin
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow, Cat, Pig, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 262-311: GDWSWVDDTP FNKVQSARFW IPGEPNNAGN NEHCGNIKAP SLQAWNDAPC, of Human Langerin. (NP_056532).



Our Abpromise guarantee covers the use of ab125476 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 37 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • FunctionCalcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
  • Tissue specificityExclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
  • Involvement in diseaseDefects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:613393]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.
  • Sequence similaritiesContains 1 C-type lectin domain.
  • DomainThe C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.
  • Cellular localizationMembrane. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
  • Information by UniProt
  • Database links
  • Alternative names
    • C type lectin domain family 4 member K antibody
    • C-type lectin domain family 4 member K antibody
    • CD 207 antibody
    • CD207 antibody
    • CD207 antigen antibody
    • CD207 antigen, langerin antibody
    • CD207 molecule antibody
    • CLC4K_HUMAN antibody
    • CLEC 4K antibody
    • CLEC4K antibody
    • Langerhans cell specific c type lectin antibody
    • Langerin antibody
    • RGD1565913 antibody
    see all

Anti-Langerin antibody images

  • Anti-Langerin antibody (ab125476) at 1 µg + Fetal kidney

    Predicted band size : 37 kDa

References for Anti-Langerin antibody (ab125476)

ab125476 has not yet been referenced specifically in any publications.

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Vielen Dank für Ihre Anrufe.

Wie versprochen habe ich alle unsere Langerin- bzw. TACD2-Antikörper danach geprüft, ob sie schon einmal mit Schwein getestet wurden - was leider bei keinem der Fall ist.

Daher habe ich di...

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