• Product nameAnti-Langerin antibody
    See all Langerin primary antibodies
  • Description
    Rabbit polyclonal to Langerin
  • Tested applicationsSuitable for: WB, IHC-FoFrmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    Synthetic peptide:


    , corresponding to N terminal amino acids 36-44 of Mouse Langerin (Genbank Accession No. CAC82936).

  • Positive control
    • Mouse lung tissue lysate



Our Abpromise guarantee covers the use of ab22111 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesIHC-FoFr: 1/5000 - 1/10000 (PMID 19712927).
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 36 kDa (predicted molecular weight: 37 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCalcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
    • Tissue specificityExclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
    • Involvement in diseaseDefects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:613393]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.
    • Sequence similaritiesContains 1 C-type lectin domain.
    • DomainThe C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.
    • Cellular localizationMembrane. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
    • Information by UniProt
    • Database links
    • Alternative names
      • C type lectin domain family 4 member K antibody
      • C-type lectin domain family 4 member K antibody
      • CD 207 antibody
      • CD207 antibody
      • CD207 antigen antibody
      • CD207 antigen, langerin antibody
      • CD207 molecule antibody
      • CLC4K_HUMAN antibody
      • CLEC 4K antibody
      • CLEC4K antibody
      • Langerhans cell specific c type lectin antibody
      • Langerin antibody
      • RGD1565913 antibody
      see all

    Anti-Langerin antibody images

    • All lanes : Anti-Langerin antibody (ab22111) at 2 µg/ml

      Lane 1 : Mouse lung tissue lysate
      Lane 2 : Mouse lung tissue lysate with Preincubation with immunizing peptide

      Predicted band size : 37 kDa
      Observed band size : 36 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 30 kDa,70 kDa. We are unsure as to the identity of these extra bands.

    References for Anti-Langerin antibody (ab22111)

    This product has been referenced in:
    • Hara Y  et al. Up-regulation of vascular endothelial growth factor expression by adenosine through adenosine A2 receptors in the rat tongue treated with endotoxin. Arch Oral Biol 54:932-42 (2009). IHC-FoFr ; Rat . Read more (PubMed: 19712927) »
    • Yu X  et al. Engagement of CD47 inhibits the contact hypersensitivity response via the suppression of motility and B7 expression by Langerhans cells. J Invest Dermatol 126:797-807 (2006). Read more (PubMed: 16456531) »

    See all 2 Publications for this product

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