Overview

  • Product name
  • Description
    Rabbit polyclonal to LAP1
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide conjugated to KLH corresponding to the N-terminal residues of Human LAP1.

  • Positive control
    • Human Brain (Cortex) tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab115168 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 172 kDa.
ELISA Use a concentration of 1 µg/ml.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.
  • Tissue specificity
    Brain-specific. Isoform 3 is ubiquitously expressed.
  • Sequence similarities
    Belongs to the LAP (LRR and PDZ) protein family.
    Contains 17 LRR (leucine-rich) repeats.
    Contains 1 PDZ (DHR) domain.
  • Cellular localization
    Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.
  • Information by UniProt
  • Database links
  • Alternative names
    • Densin 180 antibody
    • Densin antibody
    • Densin-180 antibody
    • densin180 antibody
    • DKFZp686I1147 antibody
    • KIAA1365 antibody
    • Lamin associated polypeptide 1 antibody
    • LAP 1 antibody
    • Leucine rich repeat containing 7 antibody
    • Leucine rich repeat containing protein 7 antibody
    • Leucine-rich repeat-containing protein 7 antibody
    • Lrrc 7 antibody
    • LRRC7 antibody
    • LRRC7_HUMAN antibody
    • MGC144918 antibody
    • OTTHUMP00000065336 antibody
    • OTTHUMP00000065337 antibody
    • OTTHUMP00000065338 antibody
    • Protein Lap 1 antibody
    • Protein lap1 antibody
    see all

Images

  • Immunohistochemistry Image of Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with ab115168 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References

ab115168 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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