Overview

  • Product name
  • Description
    Goat polyclonal to LARGE
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chicken, Cow, Dog
  • Immunogen

    Synthetic peptide:

    SEADVNSENLQKQ

    by a Cysteine residue linker, corresponding to internal sequence amino acids 421-433 of Human LARGE (NP_004728.1)

  • Positive control
    • Human Kidney lysate, Human Heart lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab101718 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 88 kDa.

Target

  • Function
    Glycosyltransferase which participates in glycosylation of alpha-dystroglycan. May carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. May be involved in the addition of a repeated disaccharide unit.
  • Tissue specificity
    Ubiquitous. Highest expression in heart, brain and skeletal muscle.
  • Pathway
    Protein modification; protein glycosylation.
  • Involvement in disease
    Muscular dystrophy-dystroglycanopathy congenital with mental retardation B6
    Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A6
  • Sequence similarities
    Belongs to the glycosyltransferase 8 family.
  • Cellular localization
    Golgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Acetylglucosaminyltransferase like protein antibody
    • Acetylglucosaminyltransferase-like 1A antibody
    • Acetylglucosaminyltransferase-like protein antibody
    • Glycosyltransferase-like protein LARGE1 antibody
    • KIAA0609 antibody
    • Large antibody
    • LARGE_HUMAN antibody
    • LARGE1 antibody
    • Like acetylglucosaminyltransferase antibody
    • Like glycosyltransferase antibody
    • MDC1D antibody
    • MDDGA6 antibody
    • MDDGB6 antibody
    see all

Images

  • Anti-LARGE antibody (ab101718) at 1 µg/ml + Human Kidney lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 88 kDa

References

This product has been referenced in:

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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