Overview

  • Product nameAnti-LATS2 antibody
    See all LATS2 primary antibodies
  • Description
    Rabbit polyclonal to LATS2
  • Tested applicationsSuitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from an internal sequence of Human LATS2.

  • Positive control
    • HepG2 cells; Human skeletal muscle tissue.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab111054 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF 1/100 - 1/500.

Target

  • FunctionNegative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor.
  • Tissue specificityExpressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined.
  • Sequence similaritiesBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 protein kinase domain.
    Contains 1 UBA domain.
  • Post-translational
    modifications
    Autophosphorylated and phosphorylated during M-phase and the G1/S-phase of the cell cycle. Phosphorylated and activated by STK3.
  • Cellular localizationCytoplasm > cytoskeleton > centrosome. Cytoplasm. Cytoplasm > cytoskeleton > spindle pole. Co-localizes with STK6 at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ13161 antibody
    • Kinase phosphorylated during mitosis protein antibody
    • KPM antibody
    • Large tumor suppressor homolog 2 antibody
    • Large tumor suppressor homolog 2 Drosophila antibody
    • Large tumor suppressor kinase 2 antibody
    • LATS large tumor suppressor Drosophila homolog 2 antibody
    • LATS large tumor suppressor homolog 2 antibody
    • Lats2 antibody
    • LATS2_HUMAN antibody
    • Serine/threonine kinase kpm antibody
    • Serine/threonine protein kinase kpm antibody
    • Serine/threonine-protein kinase kpm antibody
    • Serine/threonine-protein kinase LATS2 antibody
    • Warts like kinase antibody
    • Warts-like kinase antibody
    see all

Anti-LATS2 antibody images

  • ab111054 at 1/100 dilution staining LATS2 in HepG2 cells by Immunofluorescence. The image on the right is treated with the synthesized peptide.
  • ab110541 at 1/50 dilution staining LATS2 in paraffin-embedded Human Skeletal muscle tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

References for Anti-LATS2 antibody (ab111054)

ab111054 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab111054.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"