Overview

  • Product name
  • Description
    Rabbit polyclonal to LCLAT1
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence, corresponding to amino acids 231-307 (LHPRTTGFTF VVDRLREGKN LDAVHDITVA YPHNIPQSEK HLLQGDFPRE IHFHVHRYPI DTLPTSKEDL QLWCHKR) of Human LCLAT1.

  • Positive control
    • Human heart muscle tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab122197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages.
  • Tissue specificity
    Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta.
  • Pathway
    Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
  • Sequence similarities
    Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
  • Domain
    The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 1-acylglycerol-3-phosphate O-acyltransferase 8 antibody
    • 1-AGP acyltransferase 8 antibody
    • 1-AGPAT 8 antibody
    • 1AGPAT8 antibody
    • Acyl-CoA:lysocardiolipin acyltransferase 1 antibody
    • AGPAT8 antibody
    • ALCAT1 antibody
    • HSRG1849 antibody
    • lclat1 antibody
    • LCLT1_HUMAN antibody
    • LYCAT antibody
    • Lysocardiolipin acyltransferase 1 antibody
    • UNQ1849 antibody
    • UNQ1849/PRO3579 antibody
    see all

Anti-LCLAT1 antibody images

  • ab122197 at 1/450 dilution staining LCLAT1 in Paraffin-embedded Human Heart muscle tissue by Immunohistochemistry.

References for Anti-LCLAT1 antibody (ab122197)

ab122197 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab122197.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up