Overview

  • Product nameAnti-LDB3 antibody
    See all LDB3 primary antibodies
  • Description
    Rabbit polyclonal to LDB3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Guinea pig, Cow, Cat
  • Immunogen

    A 14-22 amino acid region within synthetic peptide: SYNLSLTLQK SKRPIPISTT APPVQTPLPV IPHQKDPALD TNGSLVAPSP, corresponding to N terminal amino acids 73-122 of Human LDB3

  • Positive control
    • Fetal heart cell lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab62179 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.625 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 77 , 36 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionMay function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
  • Tissue specificityExpressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta.
  • Involvement in diseaseDefects in LDB3 are the cause of cardiomyopathy dilated type 1C (CMD1C) [MIM:601493]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in LDB3 are the cause of left ventricular non-compaction type 3 (LVNC3) [MIM:601493]. Left ventricular non-compaction is characterized by numerous prominent trabeculations and deep intertrabecular recesses in hypertrophied and hypokinetic segments of the left ventricle.
    Defects in LDB3 are the cause of myopathy myofibrillar ZASP-related (MFM-ZASP) [MIM:609452]. A neuromuscular disorder characterized by distal and proximal muscle weakness with signs of cardiomyopathy and neuropathy.
  • Sequence similaritiesContains 3 LIM zinc-binding domains.
    Contains 1 PDZ (DHR) domain.
  • Cellular localizationCytoplasm > perinuclear region. Cell projection > pseudopodium. Cytoplasm > cytoskeleton. Cytoplasm > myofibril > sarcomere > Z line. Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines.
  • Information by UniProt
  • Database links
  • Alternative names
    • CMD1C antibody
    • CYPHER antibody
    • HGNC:15710 antibody
    • KIAA01613 antibody
    • KIAA0613 antibody
    • Ldb3 antibody
    • LDB3_HUMAN antibody
    • LDB3Z1 antibody
    • LDB3Z4 antibody
    • LIM domain binding 3 antibody
    • LIM domain binding protein 3 antibody
    • LIM domain-binding protein 3 antibody
    • LVNC3 antibody
    • ORACLE antibody
    • PDLIM6 antibody
    • PDZ and LIM domain 6 antibody
    • Protein cypher antibody
    • Z band alternatively spliced PDZ motif antibody
    • Z band alternatively spliced PDZ motif protein antibody
    • Z-band alternatively spliced PDZ-motif protein antibody
    • ZASP antibody
    see all

Anti-LDB3 antibody images

  • Anti-LDB3 antibody (ab62179) at 0.625 µg/ml + Fetal heart cell lysate at 10 µg/ml

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 77 , 36 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)

References for Anti-LDB3 antibody (ab62179)

ab62179 has not yet been referenced specifically in any publications.

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