Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceKSQNKPEDEADE
    • Amino acids251 to 262

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45811 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-LDB3 antibody (ab40840)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • CMD1C
    • CYPHER
    • HGNC:15710
    • KIAA01613
    • KIAA0613
    • Ldb3
    • LDB3_HUMAN
    • LDB3Z1
    • LDB3Z4
    • LIM domain binding 3
    • LIM domain binding protein 3
    • LIM domain-binding protein 3
    • LVNC3
    • ORACLE
    • PDLIM6
    • PDZ and LIM domain 6
    • Protein cypher
    • Z band alternatively spliced PDZ motif
    • Z band alternatively spliced PDZ motif protein
    • Z-band alternatively spliced PDZ-motif protein
    • ZASP
    see all
  • FunctionMay function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
  • Tissue specificityExpressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta.
  • Involvement in diseaseDefects in LDB3 are the cause of cardiomyopathy dilated type 1C (CMD1C) [MIM:601493]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in LDB3 are the cause of left ventricular non-compaction type 3 (LVNC3) [MIM:601493]. Left ventricular non-compaction is characterized by numerous prominent trabeculations and deep intertrabecular recesses in hypertrophied and hypokinetic segments of the left ventricle.
    Defects in LDB3 are the cause of myopathy myofibrillar ZASP-related (MFM-ZASP) [MIM:609452]. A neuromuscular disorder characterized by distal and proximal muscle weakness with signs of cardiomyopathy and neuropathy.
  • Sequence similaritiesContains 3 LIM zinc-binding domains.
    Contains 1 PDZ (DHR) domain.
  • Cellular localizationCytoplasm > perinuclear region. Cell projection > pseudopodium. Cytoplasm > cytoskeleton. Cytoplasm > myofibril > sarcomere > Z line. Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines.
  • Information by UniProt

References for LDB3 peptide (251-262) (ab45811)

ab45811 has not yet been referenced specifically in any publications.

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