Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
RelevanceWhen too much LDL cholesterol circulates in the blood, it can slowly build up in the inner walls of the arteries that feed the heart and brain. Together with other substances it can form plaque, a thick, hard deposit that can clog those arteries. This condition is known as atherosclerosis. Oxidized lipoproteins are formed by free radical damage to lipids that accumulate in macrophages and smooth muscle cells causing foam cell formation, an initial step in the disease.
Cellular localizationSecreted (probable)
References for Anti-LDL (Copper oxidized) antibody (ab14519)
This product has been referenced in:
Li R et al. Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins. Am J Physiol Gastrointest Liver Physiol300:G71-81 (2011).
Read more (PubMed: 21030611) »
Dong Y et al. Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo. Diabetes59:1386-96 (2010).
Read more (PubMed: 20299472) »