Anti-LDL (Copper oxidized) antibody (ab14519)

Overview

  • Product nameAnti-LDL (Copper oxidized) antibody
  • Description
    Rabbit polyclonal to LDL (Copper oxidized)
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human Cu2+ oxidised LDL.

Applications

Our Abpromise guarantee covers the use of ab14519 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
IHC-P
  • Application notesELISA: 1/500 - 1/5000.
    IHC-P: <1/500.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceWhen too much LDL cholesterol circulates in the blood, it can slowly build up in the inner walls of the arteries that feed the heart and brain. Together with other substances it can form plaque, a thick, hard deposit that can clog those arteries. This condition is known as atherosclerosis. Oxidized lipoproteins are formed by free radical damage to lipids that accumulate in macrophages and smooth muscle cells causing foam cell formation, an initial step in the disease.
    • Cellular localizationSecreted (probable)

    References for Anti-LDL (Copper oxidized) antibody (ab14519)

    This product has been referenced in:
    • Li R  et al. Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins. Am J Physiol Gastrointest Liver Physiol 300:G71-81 (2011). Read more (PubMed: 21030611) »
    • Dong Y  et al. Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo. Diabetes 59:1386-96 (2010). ICC/IF ; Mouse . Read more (PubMed: 20299472) »

    See all 5 Publications for this product

    Product Wall

    Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample Rat Tissue sections (Lung)
    Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Citrate buffer PH6.0
    Permeabilization No
    Specification Lung
    Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
    Fixative Paraformaldehyde
    Username

    Abcam user community

    Verified customer

    Submitted Aug 09 2015

    Thank you for your enquiry. ab14519 is the only anti-LDL "Copper oxidised" antiserum that we stock. Please can you tell me whether your customer is interested in the oxidised form of the protein or the native equivalent as our antisera carry this s...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"