Anti-LECT1 antibody - Carboxyterminal end (ab71450)

Overview

  • Product nameAnti-LECT1 antibody - Carboxyterminal end
    See all LECT1 primary antibodies
  • Description
    Rabbit polyclonal to LECT1 - Carboxyterminal end
  • Tested applicationsSuitable for: IHC-P, ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rabbit
  • Immunogen

    KLH conjugated synthetic peptide selected from the C-terminal region of human LECT1.

  • Positive control
    • NCI-H460 membrane lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab71450 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/50.
ELISA 1/1000.
WB 1/50 - 1/100. Detects a band of approximately 37 kDa.

Target

  • FunctionBifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.
  • Tissue specificityDetected in cartilage and cardiac valves (at protein level). Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level). Expression is decreased cardiac valves of patients with valvular heart disease (at protein level). Weakly expressed in chondrosarcoma.
  • Sequence similaritiesBelongs to the chondromodulin-1 family.
    Contains 1 BRICHOS domain.
  • Developmental stageExpressed at 9 weeks in developing cartilagenous bone rudiments.
  • Post-translational
    modifications
    After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.
  • Cellular localizationEndomembrane system and Secreted. Accumulated in the inter-territorial matrix of cartilage.
  • Information by UniProt
  • Database links
  • Alternative names
    • BRICD3 antibody
    • BRICHOS domain containing 3 antibody
    • CH-SP antibody
    • CHM I antibody
    • ChM-I antibody
    • CHM1 antibody
    • chondromodulin antibody
    • Chondromodulin I antibody
    • Chondromodulin-1 antibody
    • Chondromodulin-I antibody
    • Chondrosurfactant protein antibody
    • LECT 1 antibody
    • Lect1 antibody
    • LECT1_HUMAN antibody
    • Leukocyte cell derived chemotaxin 1 antibody
    • Multiple myeloma tumor suppressor 1 antibody
    • MYETS1 antibody
    see all

Anti-LECT1 antibody - Carboxyterminal end images

  • Anti-LECT1 antibody - Carboxyterminal end (ab71450) at 1/60 dilution + NCI-H460 cell line lysates at 12.5 µg

    Observed band size : 37 kDa (why is the actual band size different from the predicted?)
  • Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with LECT1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

References for Anti-LECT1 antibody - Carboxyterminal end (ab71450)

ab71450 has not yet been referenced specifically in any publications.

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