Overview

  • Product nameAnti-LEFTY2 antibody
    See all LEFTY2 primary antibodies
  • Description
    Mouse monoclonal to LEFTY2
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 77-180 of human LEFTY2 protein (NP_003231) with a proprietary tag.

  • Positive control
    • Human skeletal muscle tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab88088 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 41 kDa.
ELISA Use at an assay dependent dilution.

Target

  • FunctionRequired for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
  • Tissue specificityMesenchymal cells of the endometrial stroma.
  • Involvement in diseaseDefects in LEFTY2 are the cause of left-right axis malformations (LRAM) [MIM:601877]. The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.
  • Sequence similaritiesBelongs to the TGF-beta family.
  • Developmental stageTransiently expressed before and during menstrual bleeding.
  • Post-translational
    modifications
    The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • EBAF antibody
    • Endometrial bleeding associated factor (left right determination factor A transforming growth factor beta superfamily) antibody
    • Endometrial bleeding associated factor antibody
    • Endometrial bleeding-associated factor antibody
    • Left right determination factor 2 antibody
    • Left right determination factor A antibody
    • Left-right determination factor 2 antibody
    • Left-right determination factor A antibody
    • LEFTA antibody
    • LEFTY 2 antibody
    • LEFTY2 antibody
    • LEFTYA antibody
    • LFTY2 transforming growth factor, beta -4 antibody
    • LFTY2, mouse, homolog of antibody
    • LFTY2_HUMAN antibody
    • MGC46222 antibody
    • Protein lefty 2 antibody
    • Protein lefty A antibody
    • Protein lefty-2 antibody
    • Protein lefty-A antibody
    • Protein lefty2 antibody
    • PSEC0024 antibody
    • TGF beta 4 antibody
    • TGF-beta-4 antibody
    • TGFB4 antibody
    • Transforming growth factor beta 4 antibody
    • Transforming growth factor beta-4 antibody
    see all

Anti-LEFTY2 antibody images

  • Anti-LEFTY2 antibody (ab88088) at 5 µg/ml + human skeletal muscle lysate at 50 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 41 kDa
    Observed band size : 48 kDa (why is the actual band size different from the predicted?)

References for Anti-LEFTY2 antibody (ab88088)

ab88088 has not yet been referenced specifically in any publications.

Product Wall

Vielen Dank für Ihre Anfrage.

Da die beiden Proteine sehr homolog sind und das Immunogen im Speziellen eine Homologie von 98% aufweist, gehen wir davon aus, dass LEFTY1 von ab88088 auch erkannt wird.

Dies wurde jedoch nicht exp...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"