Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
Mesenchymal cells of the endometrial stroma.
Involvement in disease
Defects in LEFTY2 are the cause of left-right axis malformations (LRAM) [MIM:601877]. The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.
Belongs to the TGF-beta family.
Transiently expressed before and during menstrual bleeding.
The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.