Overview

  • Product nameAnti-LEPRE1 antibody
    See all LEPRE1 primary antibodies
  • Description
    Mouse monoclonal to LEPRE1
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: DPRVREVMNQ NLAYYAAMLG EEHTRSIGPR ESAKEYRQRS LLEKELLFFA YDVFGIPFVD PDSWTPEEVI PKRLQEKQKS ERETAVRISQ EIGNLMKEIE , corresponding to amino acids 1-100 of Human LEPRE1

Properties

Applications

Our Abpromise guarantee covers the use of ab56385 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-P
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 6 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionBasement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts.
    • Involvement in diseaseDefects in LEPRE1 are the cause of osteogenesis imperfecta type 8 (OI8) [MIM:610915]. A connective tissue disorder characterized by disproportionate short stature, severe osteoporosis, shortening of the long bones, white sclerae, a round face and a short barrel-shaped chest.
    • Sequence similaritiesBelongs to the leprecan family.
      Contains 1 Fe2OG dioxygenase domain.
      Contains 4 TPR repeats.
    • Post-translational
      modifications
      O-glycosylated; chondroitin sulfate.
    • Cellular localizationEndoplasmic reticulum. Secreted > extracellular space > extracellular matrix. Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan.
    • Information by UniProt
    • Database links
    • Alternative names
      • GROS 1 antibody
      • GROS1 antibody
      • Growth suppressor 1 antibody
      • LEPRE 1 antibody
      • Lepre1 antibody
      • Leprecan 1 antibody
      • Leprecan antibody
      • Leprecan-1 antibody
      • Leprecan1 antibody
      • Leucine proline enriched proteoglycan (leprecan) 1 antibody
      • Leucine proline enriched proteoglycan 1 antibody
      • Leucine- and proline-enriched proteoglycan 1 antibody
      • MGC117314 antibody
      • OI8 antibody
      • P3H1 antibody
      • P3H1_HUMAN antibody
      • Prolyl 3 hydroxylase 1 antibody
      • Prolyl 3-hydroxylase 1 antibody
      see all

    Anti-LEPRE1 antibody images

    • LEPRE1 antibody (ab56385) used in immunohistochemistry at 6ug/ml on formalin fixed and paraffin embedded human esophagus.


    • Predicted band size : 91 kDa
      LEPRE1 antibody (ab56385) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References for Anti-LEPRE1 antibody (ab56385)

    ab56385 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab56385.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"