Anti-LEPRE1 antibody - Carboxyterminal end (ab60040)

Overview

  • Product nameAnti-LEPRE1 antibody - Carboxyterminal end
    See all LEPRE1 primary antibodies
  • Description
    Rabbit polyclonal to LEPRE1 - Carboxyterminal end
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (10-30 aa in length) at the C-terminal of last 50 aa of human LEPRE1 conjugated to KLH

  • Positive control
    • Human hepatocarcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab60040 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
IHC-P 1/50 - 1/100.

Target

  • FunctionBasement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts.
  • Involvement in diseaseDefects in LEPRE1 are the cause of osteogenesis imperfecta type 8 (OI8) [MIM:610915]. A connective tissue disorder characterized by disproportionate short stature, severe osteoporosis, shortening of the long bones, white sclerae, a round face and a short barrel-shaped chest.
  • Sequence similaritiesBelongs to the leprecan family.
    Contains 1 Fe2OG dioxygenase domain.
    Contains 4 TPR repeats.
  • Post-translational
    modifications
    O-glycosylated; chondroitin sulfate.
  • Cellular localizationEndoplasmic reticulum. Secreted > extracellular space > extracellular matrix. Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan.
  • Information by UniProt
  • Database links
  • Alternative names
    • GROS 1 antibody
    • GROS1 antibody
    • Growth suppressor 1 antibody
    • LEPRE 1 antibody
    • Lepre1 antibody
    • Leprecan 1 antibody
    • Leprecan antibody
    • Leprecan-1 antibody
    • Leprecan1 antibody
    • Leucine proline enriched proteoglycan (leprecan) 1 antibody
    • Leucine proline enriched proteoglycan 1 antibody
    • Leucine- and proline-enriched proteoglycan 1 antibody
    • MGC117314 antibody
    • OI8 antibody
    • P3H1 antibody
    • P3H1_HUMAN antibody
    • Prolyl 3 hydroxylase 1 antibody
    • Prolyl 3-hydroxylase 1 antibody
    see all

Anti-LEPRE1 antibody - Carboxyterminal end images

  • ab60040 at 1/50 dilution staining LEPRE1 in Human hepatocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. A peroxidase-conjugated secondary antibody was used, followed by AEC staining.

References for Anti-LEPRE1 antibody - Carboxyterminal end (ab60040)

ab60040 has not yet been referenced specifically in any publications.

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