Overview

  • Product name
  • Description
    Rabbit polyclonal to LEPREL1
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence, corresponding to amino acids 177-288 of Human LEPREL1.

  • Positive control
    • Human placenta tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab121393 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types IV and V.
  • Tissue specificity
    Expressed in heart, placenta, lung, liver, skeletal muscle and kidney. Expression localized to the epithelia of bile ducts and to the sacroplasm of heart muscle and skeletal muscle. In the pancreas, localized to a subpopulation of Langerhans islet cells and in the salivary gland, expressed in acinar cells.
  • Sequence similarities
    Belongs to the leprecan family.
    Contains 1 Fe2OG dioxygenase domain.
    Contains 4 TPR repeats.
  • Cellular localization
    Endoplasmic reticulum. Golgi apparatus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4832416N06 antibody
    • AW553532 antibody
    • Leprecan like 1 antibody
    • Leprecan-like protein 1 antibody
    • Leprel1 antibody
    • MCVD antibody
    • MLAT4 antibody
    • Myxoid liposarcoma-associated protein 4 antibody
    • P3H2 antibody
    • P3H2_HUMAN antibody
    • Prolyl 3 hydroxylase 3 antibody
    • Prolyl 3-hydroxylase 2 antibody
    see all

Images

  • ab121393, at 1/50 dilution, staining LEPREL1 in paraffin-embedded Human placenta tissue by Immunohistochemistry, showing strong cytoplasmic positivity in trophoblastic cells and decidual cells.

References

ab121393 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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