Anti-Leptin Receptor antibody (ab7212)

Overview

• Product nameAnti-Leptin Receptor antibody
  See all Leptin Receptor primary antibodies
• Description
  Rabbit polyclonal to Leptin Receptor
• SpecificityRecombinant and natural mouse OB receptor.
• Tested applicationsSuitable for: WBmore details
• Species reactivity
  Reacts with: Mouse
  
• Immunogen

  Recombinant fragment, corresponding to amino acids 217-376 of Mouse Leptin Receptor. Expressed in E. coli

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• Storage bufferPreservative: 0.1% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityProtein A purified
• ClonalityPolyclonal
• IsotypeIgG
• Research areas
  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

  • Cardiovascular
  • Lipids / Lipoproteins
  • Fatty Acids
  • Metabolism

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of lipids and lipoproteins

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipid metabolism

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Fatty acids

  • Metabolism
  • Types of disease
  • Obesity

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Redox metabolism
  • Fatty acid oxidation

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

Applications

Target

• FunctionReceptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway.
• Tissue specificityIsoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
• Sequence similaritiesBelongs to the type I cytokine receptor family. Type 2 subfamily.
  Contains 4 fibronectin type-III domains.
  Contains 1 Ig-like (immunoglobulin-like) domain.
• DomainThe cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs.
  The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  The box 1 motif is required for JAK interaction and/or activation.
• Post-translational
  modificationsOn ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3 (By similarity). Phosphorylation on Tyr-1141 is required for STAT3 binding/activation.
• Cellular localizationSecreted and Cell membrane.

• Target information above from: UniProt accession P48357 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 16847 Mouse
  • SwissProt: P48356 Mouse
  • Unigene: 259282 Mouse
• Alternative names
  • CD 295 antibody
  • CD295 antibody
  • CD295 antigen antibody

  • Db antibody
  • Fa antibody
  • HuB219 antibody
  • LEP R antibody
  • LEP-R antibody
  • LEPR antibody
  • LEPR_HUMAN antibody
  • LEPRD antibody
  • Leptin receptor antibody
  • Leptin receptor fatty antibody
  • Leptin receptor gene related protein antibody
  • Leptin receptor precursor antibody
  • Leptin receptor precursor antibody
  • OB R gene related protein antibody
  • OB receptor antibody
  • OB-R antibody
  • OB-RGRP antibody
  • obl antibody
  • Obr antibody

  see all