Anti-Leucyl-cystinyl aminopeptidase antibody (ab107450)

Overview

  • Product nameAnti-Leucyl-cystinyl aminopeptidase antibody
    See all Leucyl-cystinyl aminopeptidase primary antibodies
  • Description
    Rabbit polyclonal to Leucyl-cystinyl aminopeptidase
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide between N terminal amino acids 16-46 of Human Leucyl-cystinyl aminopeptidase (NP_005566.2 , NP_787116.2), conjugated to KLH.

  • Positive control
    • HL60 cell lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab107450 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 117 kDa.

Target

  • FunctionRelease of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.
  • Tissue specificityHighly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon.
  • Sequence similaritiesBelongs to the peptidase M1 family.
  • Post-translational
    modifications
    The pregnancy serum form is derived from the membrane-bound form by proteolytic processing.
    N-glycosylated.
  • Cellular localizationCell membrane. In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases and Secreted. During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.
  • Information by UniProt
  • Database links
  • Alternative names
    • angiotensin IV receptor antibody
    • AT (4) receptor antibody
    • CAP antibody
    • Cystinyl aminopeptidase antibody
    • insulin regulated aminopeptidase antibody
    • insulin regulated membrane aminopeptidase antibody
    • insulin responsive aminopeptidase antibody
    • Insulin-regulated membrane aminopeptidase antibody
    • Insulin-responsive aminopeptidase antibody
    • IRAP antibody
    • LCAP_HUMAN antibody
    • Leucyl-cystinyl aminopeptidase antibody
    • LNPEP antibody
    • OTase antibody
    • Oxytocinase antibody
    • P-LAP antibody
    • Placental leucine aminopeptidase antibody
    • PLAP antibody
    • pregnancy serum form antibody
    • vasopressinase antibody
    see all

Anti-Leucyl-cystinyl aminopeptidase antibody images

  • Anti-Leucyl-cystinyl aminopeptidase antibody (ab107450) at 1/100 dilution + HL60 cell lysate at 35 µg

    Predicted band size : 117 kDa

References for Anti-Leucyl-cystinyl aminopeptidase antibody (ab107450)

ab107450 has not yet been referenced specifically in any publications.

Product Wall

I have asked our commercial team to add the blocking peptide to ab107450. This can now be purchased under reference number ab185019.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"