(S)-enantiomer of bupivacaine (ab142490). Reversible sodium channel inhibitor. Acts via blockade of voltage-sensitive ion channels in neuronal membranes, preventing transmission of nerve impulses. Efficacy is similar to that of bupivacaine with a reduced risk of cardiotoxicity.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Vladimirov M et al. Potency of bupivacaine stereoisomers tested in vitro and in vivo: biochemical, electrophysiological, and neurobehavioral studies. Anesthesiology93:744-55 (2000).
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Kanai Y et al. Comparisons of the anesthetic potency and intracellular concentrations of S(-) and R() bupivacaine and ropivacaine in crayfish giant axon in vitro. Anesth Analg90:415-20 (2000).
Read more (PubMed: 10648331) »
Gristwood RW & Greaves JL Levobupivacaine: a new safer long acting local anaesthetic agent. Expert Opin Investig Drugs8:861-76 (1999).
Read more (PubMed: 15992136) »